![]() ![]() Personalized medicine holds tremendous promise for improving safety and efficacy of drug therapies by optimizing treatment regimens. The enhancement in image resolution and maintenance of quantitative information from the image deconvolution leads to greater statistical significance in the analysis of nuclear translocation. The ImageXpress Pico system with Digital Confocal 2D on-the-fly deconvolution is capable of measuring the translocation of proteins from the cytoplasm to the nucleus, like NF-κB translocation upon treatment with TNF-α. Assays requiring precise identification of sub-cellular structures or molecules within different cellular compartments can benefit from the ability of image deconvolution to improve identification of the specific fluorescence signal against potentially high background caused by out-of-focus light. Once in the nucleus, these proteins can regulate the expression of target genes. In many cases, the initiation of these pathways by extracellular signals, such as hormones or cytokines, leads to the translocation of proteins from the cytoplasm to the nucleus. The ability of cells to adapt to their environment is mediated by highly controlled signaling pathways. High-Content Screening with AgileOptix Technology.PROTEIN DETECTION, QUANTITATION, ANALYSIS.NUCLEIC ACID (DNA/RNA) DETECTION & ANALYSIS.SpectraTest Validation Plates and Recertification.GXP SOFTWARE INSTALLATION AND VALIDATION.HIGH-THROUGHPUT, HIGH CONTENT SCREENING.COVID-19 RESPONSE - We are committed to supporting our scientific community during this pandemic. ![]()
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